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Foliage Gallery Misc. Gallery Contributors' Gallery Pnas proceedings of the national academy of sciences of the united states of america skip to main page content info for authors editorial board about subscribe advertise contact feedback site map adjuvant solution for pandemic influenza vaccine production christopher h. Clegg a , 1 , richard roque a , neal van hoeven b , lucy perrone a , susan l. Baldwin b , joseph a. Rininger c , richard a. viagra viagra women Bowen d , and steven g. Reed b , e atria bioscience corp. , seattle, wa 98104; binfectious disease research institute, seattle, wa 98104; cprotein sciences corporation, meriden, ct 06450; ddepartment of biomedical sciences, colorado state university, fort collins, co 80523; and eimmune design corp. , seattle, wa 98104 edited by barry r. Bloom, harvard school of public health, boston, ma, and approved september 10, 2012 (received for review may 1, 2012) abstract extensive preparation is underway to mitigate the next pandemic influenza outbreak. New vaccine technologies intended to supplant egg-based production methods are being developed, with recombinant hemagglutinin (rha) as the most advanced program for preventing seasonal and avian h5n1 influenza. Increased efforts are being focused on adjuvants that can broaden vaccine immunogenicity against emerging viruses and maximize vaccine supply on a worldwide scale. viagra bayer gsk Here, we test protection against avian flu by using h5n1-derived rha and gla-se, a two-part adjuvant system containing glucopyranosyl lipid adjuvant (gla), a formulated synthetic toll-like receptor 4 agonist, and a stable emulsion (se) of oil in water, which is similar to the best-in-class adjuvants being developed for pandemic flu. Notably, a single submicrogram dose of rh5 adjuvanted with gla-se protects mice and ferrets against a high titer challenge with h5n1 virus. Gla-se, relative to emulsion alone, accelerated induction of the primary immune response and broadened its durability against heterosubtypic h5n1 virus challenge. Mechanistically, gla-se augments protection via induction of a th1-mediated antibody response. Ar-r liquid viagra Innate signaling pathways that amplify priming of th1 cd4 t cells will likely improve vaccine performance against future outbreaks of lethal pandemic flu. Footnotes ↵ 1to whom correspondence should be addressed. viagra viagra women E-mail: cclegg{at}triabio. Com. Author contributions: c. H. C. , n. V. H. , l. P. , s. L. B. , r. A. online doctor consultation viagra B. , and s. G. R. cheap viagra online Designed research; r. Viagra lilly coupon R. buying viagra , n. cheap viagra V. H. buy generic viagra , l. viagra without a doctor prescription P. cheap viagra for sale , and r. A. B. buy generic viagra usa Performed research; j. A. R. Contributed new reagents/analytic tools; c. H. C. , r. R. viagra viagra women , n. V. H. , l. P. , and s. L. B. Analyzed data; and c. H. C. And s. G. cheap viagra R. Wrote the paper. viagra sale Conflict of interest statement: c. H. C. Viagra ukrainian band Is a full-time employee of tria bioscience, is a consultant for immune design corp. , and has equity in immune design; n. howtosmudge.com/pjn-cheap-generic-viagra-online-bn/ V. H. Has equity in immune design; j. A. cheap generic viagra R. Was a full-time employee of protein sciences corp. ; and s. G. R. Is an inventor on gla patents licensed by immune design and has equity in immune design. This article. viagra online New Stuff Links Awards E-mail me



Welcome to my photo site. My love for photography developed about 30 years ago, in college, when I learned how to develop and print black & white photographs. I've always joked that in college I spent more time in the darkroom than in the classroom. When the college yearbook asked me to work for them I was issued my first press pass. Since those days of black & white, my interests evolved into color prints, then slides, and now digital images. Above you will find links to several of my galleries. Feel free to browse the picture galleries and e-mail me your comments at alexbratu@yahoo.com or use the e-mail link above. Browse the Free Wallpaper gallery and download an image to use as your desktop background.

Alex Bratu
P.O. Box 3319
Milford, CT 06460 USA



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This site was last updated on 04/17/10.